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Parkinson’s disease affects network of brain regions that controls whole-body action
- RESEARCH BRIEFINGS
- 25 February 2026
Parkinson’s disease affects network of brain regions that controls whole-body action
Precision brain imaging of individuals with Parkinson’s disease reveals that the affected circuit is best characterized as a previously described network of brain regions called the somato-cognitive action network. Abnormally high connectivity in this network is associated with Parkinson’s disease and is normalized by effective pharmacological treatment and various brain-stimulation therapies.
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This is a summary of: Ren, J. et al. Parkinson’s disease as a somato-cognitive action network disorder. Nature https://doi.org/10.1038/s41586-025-10059-1 (2026).
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doi: https://doi.org/10.1038/d41586-026-00573-1
‘Expert opinion’ is published under a CC BY 4.0 licence, Figure 1 is published under a CC BY-NC-ND 4.0 licence.
References
Sveinbjornsdottir, S. J. Neurochem. 139, 318–324 (2016).
Gordon, E. M. et al. Nature 617, 351–359 (2023).
Shen, L. et al. Ann. Neurol. 88, 1178–1193 (2020).
Dahmani, L. et al. npj Parkinsons Dis. 9, 90 (2023).
Ren, J. et al. Brain Stimul. 16, 1313–1321 (2023).
Read the paper: Parkinson’s disease as a somato-cognitive action network disorder
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